Pesquisa | SciELO

ABSTRACT The objective of this study is to present the protocol of a cluster randomized clinical trial to be conducted through the TeleICU project - Qualification of Intensive Care by Telemedicine. The study will consist of a cluster randomized clinical trial, open label, in pediatric intensive care units, with an allocation ratio of 1:1, to compare the intervention group (support of Telemedicine for patients admitted to the pediatric intensive care unit) with a control group (pediatric intensive care unit usual care). The study proposed to select 16 pediatric intensive care units, including 100 participants per site, with a total of 1,600 participants. The intervention group will receive telerounds from Monday to Friday and will have specialists and continuing education activities available. The primary outcome measure will be the length of stay in the pediatric intensive care unit, defined as the difference between the date of discharge of the participant and the date of admission to the intensive care unit. The secondary outcomes will be mortality rate, invasive mechanical ventilation-free days, days using antibiotics, days using vasoactive drugs and days using sedoanalgesia. This study will be conducted in accordance with Resolution 466/12 of the National Health Council, with approval by the Research Ethics Committee of the institutions involved. The present study has the potential to reproduce studies on Telemedicine in intensive care and may make important contributions to care in intensive care units in Brazil and other settings. If Telemedicine shows positive clinical care results compared to conventional treatment, more pediatric patients may benefit. ClinicalTrials.gov registry: NCT05260710

RESUMO O objetivo deste estudo será apresentar o protocolo de um ensaio clínico randomizado em cluster a ser realizado por meio do projeto TeleUTI - Qualificação da Assistência em Terapia Intensiva por Telemedicina. O estudo consistirá em um ensaio clínico randomizado por cluster, open label, em unidades de terapia intensiva pediátricas, com proporção de alocação de 1:1, com o intuito de comparar o grupo de intervenção (apoio da telemedicina para os pacientes internados na unidade de terapia intensiva pediátrica) com um grupo controle (cuidados habituais da unidade de terapia intensiva pediátrica). O estudo se propõe a selecionar 16 unidades de terapia intensiva pediátricas, incluindo 100 participantes por local, com o total de 1.600 participantes. O grupo intervenção receberá telerounds de segunda-feira a sexta-feira e terá à disposição especialistas e atividades de educação continuada. O desfecho primário a ser avaliado será o tempo de permanência nas unidades de terapia intensiva pediátricas, definido pela diferença entre a data de alta do participante com a data de admissão na unidade de terapia intensiva. Os desfechos secundários serão: taxa de mortalidade; dias livres de ventilação mecânica, dias de uso de antibióticos, dias de uso de drogas vasoativas e dias de uso de sedoanalgesia. Este estudo será conduzido em conformidade com a resolução 466/12 do Conselho Nacional de Saúde, com aprovação pelo Comitê de Ética em Pesquisa das instituições hospitalares envolvidas. O trabalho tem o potencial de reproduzir estudos sobre Telemedicina em cuidados intensivos, podendo trazer contribuições importantes ao atendimento em unidades de terapia intensiva no Brasil e em outras realidades. Se a Telemedicina mostrar resultados clínicos assistenciais positivos em relação ao tratamento convencional, mais pacientes pediátricos poderão ser beneficiados. Registro ClinicalTrials.gov: NCT05260710

https://doi.org/10.5935/2965-2774.20230223-en

Selection of F1 genotypes of pineapple and reaction to inoculation with a Fusarium guttiforme isolate
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Lira Júnior, José Severino de

; Andrade, Domingos Eduardo Guimarães Tavares de

; Bezerra, João Emmanoel Fernandes

; Assunção, Marta dos Santos

; Assis, Tereza Cristina de

; Junghans, Davi Theodoro

; Matos, Aristóteles Pires de

Crop Breeding and Applied Biotechnology

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2023, Volume 23 Nº 1 elocation e43202315

Resumo: En | Texto: En | PDF: En

Abstract Fusariosis (Fusarium guttiforme) is the most destructive disease of the pineapple crop in Brazil. The aim of this study was to evaluate the reaction to an isolate in pineapple genotypes selected for crownless fruit weight (CFW) and total soluble solids (TSS). A total of 1,125 genotypes ('BRS Imperial'×'Pérola') were evaluated. Selection for greatest CFW and TSS was performed during the sexual cycle. The isolate was inoculated on slip-type plantlets using the immersion technique. Plantlets were evaluated for disease intensity in the stem, attributing scores from 0 to 5. Eighteen genotypes were selected with values from 1.514 to 3.307 g (CFW) and from 14.6 to 19.4 °Brix (TSS). Six genotypes reached the highest level of survival against the IT-01 isolate. Selected genotypes have agronomic traits superior to those of their parents, which qualify them to be cycled back into the plant breeding program of the Instituto Agronômico de Pernambuco - IPA.

https://doi.org/10.1590/1984-70332023v23n1a5

Systematic review of reverse vaccinology and immunoinformatics data for non-viral sexually transmitted infections
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GOMES, LUCAS GABRIEL R.

; DUTRA, JOYCE C.F.

; PROFETA, RODRIGO

; DIAS, MARIANA V.

; GARCÍA, GLEN J.Y.

; RODRIGUES, DIEGO LUCAS N.

; GOÉS NETO, ARISTÓTELES

; ABURJAILE, FLÁVIA F.

; TIWARI, SANDEEP

; SOARES, SIOMAR C.

; AZEVEDO, VASCO

; JAISWAL, ARUN K.

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Supl. 2 elocation e20230617

Resumo: En | Texto: En | PDF: En

Abstract Sexually Transmitted Infections (STIs) are a public health burden rising in developed and developing nations. The World Health Organization estimates nearly 374 million new cases of curable STIs yearly. Global efforts to control their spread have been insufficient in fulfilling their objective. As there is no vaccine for many of these infections, these efforts are focused on education and condom distribution. The development of vaccines for STIs is vital for successfully halting their spread. The field of immunoinformatics is a powerful new tool for vaccine development, allowing for the identification of vaccine candidates within a bacterium’s genome and allowing for the design of new genome-based vaccine peptides. The goal of this review was to evaluate the usage of immunoinformatics in research focused on non-viral STIs, identifying fields where research efforts are concentrated. Here we describe gaps in applying these techniques, as in the case of Treponema pallidum and Trichomonas vaginalis.

https://doi.org/10.1590/0001-3765202320230617

Code infarction initiative of Bajio region, during the pandemic by COVID-19 in a reconversion hospital
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Villar-Valencia, Cristian Adrián

; Hernández-González, Martha Alicia

; Borrayo-Sánchez, Gabriela

; Celis-Quintal, Juan German

; Solorio-Meza, Sergio Eduardo

; Medina-Torres, Oscar Samuel

; Gutiérrez-Galván, Maraí Xochitl

; Rodríguez-Martínez, Braulio

; Prado-Rodríguez, Luis Humberto

; Vázquez-Morones, Ana Laura

; Alatoma-Medina, Juan Pablo

; Hernández-Estala, Jorge

; Patiño-Amaya, Aristóteles

; Magdaleno-Serrano, Hugo Ivan

; Rodríguez-Déniz, Carmen

; Arellano-Sotelo, Hugo

; Nava-Hernández, Guillermo

; Ramírez-Vázquez, Ricardo

; Chimal-Flores, Marco Antonio

; Alegría-Peredia, Emiliano

; Ramos-González, Gerardo Rubén

; Pérez-Benítez, Rigoberto

; Bermúdez-Acévez, Erik

; Valencia-Martínez, Hypatia

; Segovia-Solís, Hugo

; López-Varela, Manuel

; Monroy-Córdoba, Doryan

; Marmolejo-López, Adriana

; Báez-Montes, Alfredo

; Hernández-Cerqueda, Fabián

; Nolasco-Muñoz, Luis Ricardo

; Vargas-Ramírez, Luis Manuel

; Celis-Quintal, Juan German

; Bernal-Ruíz, Enrique Alfredo

; Delgado-Sánchez, Anabella

; Sánchez-López, José Manuel

; Bautista-López, Germán Ramón

; Acevedo-Gómez, Pablo Francisco

; Acuña-Valerio, Jorge Francisco

; González-Ortíz, Oracio

; Hernández-Padilla, Adolfo Asahel

; Solórzano-Vázquez, Marco Alejandro

; Franco-Herrera, Noel

; González, Luis Jonathan

; Reyes-Álvarez, José Miguel

; Salinas-Cavazos, Iván Rosendo

; Tiscareño-Villanueva, Ashby Daniel

; Vidrio-Villaseñor, Ramiro

; Fernández-Yáñez, Gabriel

; Meza, Ma. Guadalupe

; Nucamendi-Solórzano, Freeman Issac

; Sandoval-Uribe, José de Jesús

; Sotelo-García, Luis David

; Zamoaya-Paz, Luis Carlos

; Espriu, Donovan Fernando

; García-Rodríguez, Román

; López-Ibarra, Daniel Eugenio

; López-Valencia, Andrea Janeth

; Villar-Valencia, Cristian Adrián

; Navarro-Pérez-Macedo, Javier

Cardiovascular and metabolic science

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Set 2022, Volume 33 Nº 3 Páginas 97 - 105

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract: Introduction: Acute myocardial infarction has a high prevalence and possibility of death if timely care is not given. It is possible that treatment could be delayed during a health crisis such as the COVID-19 pandemic. Objective: The objective of this study was to evaluate the impact of the COVID-19 pandemic on the function of the infarction code in the High Specialty Medical Unit of our institution. The medical indicators of acute coronary ischemic syndrome with ST-segment elevation were compared at two times: before the COVID-19 pandemic and during it. Material and methods: An ambispective, analytical, comparative cohort study was conducted, comparing the periods of February-September 2019 and February-September 2020, in the High Specialty Medical Unit, Centro Médico del Bajío number 1, Instituto Mexicano del Seguro Social, Leon, Guanajuato, Mexico. All patients older than 18 years with clinical, electrocardiographic, and enzymatic data of acute coronary ischemic syndrome, accepted in the medical network as infarction code registered in the National Registry of Acute Coronary Ischemic Syndromes (RENASCA) electronic case report form were included in the study. Results: The independent samples t-test was used to determine the impact of the infarction code initiative based on the reperfusion therapies performed, the door-to-needle, the door-to-balloon time, and the ischemia time. There was a significant difference in the reperfusion strategy, with greater thrombolysis during the COVID-19 pandemic (57.4% versus 72.6%, odds ratio [OR] 1.97, 95% confidence interval [CI] 0.49-0.82, p < 0.001), as well as reperfusion criteria (21.03% versus 35.37%, OR 2.05, 95% CI 0.53-0.80, p < 0.0001). Mortality was not different between the time periods. Conclusions: The COVID-19 pandemic has not impacted operation of the infarction code in the High Specialty Medical Unit Centro Médico del Bajío number 1 because the medical indicators of acute coronary ischemic syndrome with ST-segment elevation did not change.

resumen está disponible en el texto completo

https://doi.org/10.35366/107622

[SciELO Preprints] - Teaching Psychology’s History in Brazil: from the Benjamin Constant Reform, to the minimum curriculum and the National Curriculum Guidelines
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Miez, Walter Aristóteles Silva, Luisa Xavier de Brito

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Data de publicação: 2022-01-03

Resumo: En Es Pt

Psychology’s History is an important theme in undergraduate Psychology curricula as a basic orientation for and discussing “epistemological and historical foundations” and the promotion of critical training. This article investigates the historical moments of the institutionalization of the teaching of the Psychology’s History in Brazil, since the Benjamin Constant Reform, passing through the Minimum Curriculum and culminating in the National Curriculum Guidelines. We intend to highlight the paths of conception and institutionalization of the discipline of Psychology’s History in Brazil, and how that consolidated as an important discussion at the academy. This work is organized analysing twelve legal documents referring to the teaching of Psychology, discussing: curricular models, perspectives that present different histories of Psychology, as well as how it’s impact on the construction of memories in the science and collaborate for professional training.

La Historia de la Psicología está incluida en los planes de estudio de Licenciatura en Psicología como una orientación básica para la formación dada su relevancia en la discusión de los “fundamentos epistemológicos e históricos” y la promoción de la formación crítica. Investigamos los momentos históricos de la institucionalización de la enseñanza de la disciplina de Historia de la Psicología en Brasil, desde la Reforma Benjamin Constant, al Currículo Mínimo y los Lineamientos Curriculares Nacionales. Destacamos la concepción e institucionalización de la Historia de la Psicología en Brasil, y los caminos que la consolidaron como campo de formación, investigación y extensión. Analisamos doce documentos legales relacionados con la enseñanza de la Psicología, discutiendo: modelos curriculares, perspectivas que presentan diferentes historias de la Psicología, su impacto en la construcción de memorias en el campo científico y la colaboración para la formación profesional.

A História da Psicologia está contemplada nos currículos da graduação em Psicologia posta como orientação base para a formação dada a sua relevância ao discutir “fundamentos epistemológicos e históricos” e a promoção de uma formação crítica. Investiga-se os momentos históricos da institucionalização do ensino da disciplina História da Psicologia no Brasil, desde a desde a Reforma Benjamin Constant, passando pelo Currículo Mínimo e culminando nas Diretrizes Curriculares Nacionais. Pretendemos, destacar os caminhos da concepção e institucionalização da disciplina da História da Psicologia no Brasil, e os caminhos que a consolidaram como um campo de formação, pesquisa e extensão. O trabalho se organiza através da análise de doze documentos legais referentes ao ensino de Psicologia, discutindo: modelos curriculares, perspectivas que apresentam diferentes histórias da Psicologia, bem como seu impacto na construção de memórias do campo científico e a colaboração para a formação profissional.

https://doi.org/10.1590/SciELOPreprints.3387

Perfil Clínico, Laboratorial e de Métodos de Imagem na Amiloidose Sistêmica em um Centro de Referência Cardiológico Brasileiro
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Fernandes, Fábio

; Alencar Neto, Aristóteles Comte de

; Bueno, Bruno Vaz Kerges

; Cafezeiro, Caio Rebouças Fonseca

; Rissato, João Henrique

; Szor, Roberta Shcolnik

; Carvalho, Mariana Lombardi Peres de

; Mathias Júnior, Wilson

; Lino, Angelina Maria Martins

; Castelli, Jussara Bianchi

; Souza, Evandro de Oliveira

; Ramires, Félix José Alvarez

; Hotta, Viviane Tiemi

; Soares Júnior, José

; Tavares, Caio de Assis Moura

; Krieger, José Eduardo

; Rochitte, Carlos Eduardo

; Dabarian, André

; Hajjar, Ludhmila Abrahão

; Kalil Filho, Roberto

; Mady, Charles

Arquivos Brasileiros de Cardiologia

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2022, Volume 118 Nº 2 Páginas 422 - 432

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento Amiloidose sistêmica é uma doença com manifestações clínicas diversas. O diagnóstico envolve suspeita clínica, aliada a métodos complementares. Objetivo Descrever o perfil clínico, laboratorial, eletrocardiográfico e de imagem no acometimento cardíaco da amiloidose sistêmica. Métodos Estudo de uma amostra de conveniência, analisando dados clínicos, laboratoriais, eletrocardiográficos, ecocardiográficos, medicina nuclear e ressonância magnética. Considerou-se significância estatística quando p < 0,05. Resultados Avaliaram-se 105 pacientes (com mediana de idade de 66 anos), sendo 62 homens, dos quais 83 indivíduos apresentavam amiloidose por transtirretina (ATTR) e 22 amiloidose por cadeia leve (AL). Na ATTR, 68,7% eram de caráter hereditário (ATTRh) e 31,3% do tipo selvagem (ATTRw). As mutações mais prevalentes foram Val142Ile (45,6%) e Val50Met (40,3%). O tempo de início dos sintomas ao diagnóstico foi 0,54 e 2,15 anos nas formas AL e ATTR (p < 0,001), respectivamente. O acometimento cardíaco foi observado em 77,9% dos ATTR e 90,9% dos AL. Observaram-se alterações de condução atrioventricular em 20% e intraventricular em 27,6% dos pacientes, sendo 33,7 % na ATTR e 4,5% das AL (p = 0,006). A forma ATTRw apresentou mais arritmias atriais que os ATTRh (61,5% x 22,8%; p = 0,001). Ao ecocardiograma a mediana da espessura do septo na ATTRw x ATTRh x AL foi de 15 mm x 12 mm x 11 mm (p = 0,193). Observou-se BNP elevado em 89,5% dos indivíduos (mediana 249 ng/mL, IQR 597,7) e elevação da troponina em 43,2%. Conclusão Foi possível caracterizar, em nosso meio, o acometimento cardíaco na amiloidose sistêmica, em seus diferentes subtipos, através da história clínica e dos métodos diagnósticos descritos.

Abstract Background Systemic amyloidosis is a disease with heterogeneous clinical manifestations. Diagnosis depends on clinical suspicion combined with specific complementary methods. Objective To describe the clinical, laboratory, electrocardiographic, and imaging profile in patients with systemic amyloidosis with cardiac involvement. Methods This study was conducted with a convenience sample, analyzing clinical, laboratory, electrocardiographic, echocardiographic, nuclear medicine, and magnetic resonance data. Statistical significance was set at p < 0.05. Results A total of 105 patients were evaluated (median age of 66 years), 62 of whom were male. Of all patients, 83 had transthyretin (ATTR) amyloidosis, and 22 had light chain (AL) amyloidosis. With respect to ATTR cases, 68.7% were the hereditary form (ATTRh), and 31.3% were wild type (ATTRw). The most prevalent mutations were Val142Ile (45.6%) and Val50Met (40.3%). Time from onset of symptoms to diagnosis was 0.54 and 2.15 years, in the AL and ATTR forms, respectively (p < 0.001). Cardiac involvement was observed in 77.9% of patients with ATTR and in 90.9% of those with AL. Alterations were observed in atrioventricular and intraventricular conduction in 20% and 27.6% of patients, respectively, with 33.7% in ATTR and 4.5% in AL (p = 0.006). In the ATTRw form, there were more atrial arrhythmias than in ATTRh (61.5% versus 22.8%; p = 0.001). On echocardiogram, median septum thickness in ATTRw, ATTRh, and AL was 15 mm, 12 mm, and 11 mm, respectively (p = 0.193). Elevated BNP was observed in 89.5% of patients (median 249, ICR 597.7), and elevated troponin was observed in 43.2%. Conclusion In this setting, it was possible to characterize cardiac involvement in systemic amyloidosis in its different subtypes by means of clinical history and the diagnostic methods described.

https://doi.org/10.36660/abc.20201003

Posicionamento sobre Diagnóstico e Tratamento da Amiloidose Cardíaca – 2021
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Simões, Marcus V.

; Fernandes, Fabio

; Marcondes-Braga, Fabiana G.

; Scheinberg, Philip

; Correia, Edileide de Barros

; Rohde, Luis Eduardo P.

; Bacal, Fernando

; Alves, Silvia Marinho Martins

; Mangini, Sandrigo

; Biolo, Andréia

; Beck-da-Silva, Luis

; Szor, Roberta Shcolnik

; Marques Junior, Wilson

; Oliveira, Acary Souza Bulle

; Cruz, Márcia Waddington

; Bueno, Bruno Vaz Kerges

; Hajjar, Ludhmila Abrahão

; Issa, Aurora Felice Castro

; Ramires, Felix José Alvarez

; Coelho Filho, Otavio Rizzi

; Schmidt, André

; Pinto, Ibraim Masciarelli Francisco

; Rochitte, Carlos Eduardo

; Valicelli, Flávio Henrique

; Vieira, Marcelo Luiz Campos

; Mesquita, Cláudio Tinoco

; Ramos, Celso Dario

; Soares-Junior, José

; Romano, Minna Moreira Dias

; Mathias Junior, Wilson

; Garcia Junior, Marcelo Iório

; Montera, Marcelo Westerlund

; Melo, Marcelo Dantas Tavares de

; Silva, Sandra Marques e

; Garibaldi, Pedro Manoel Marques

; Alencar Neto, Aristóteles Comte de

; Lopes, Renato Delascio

; Ávila, Diane Xavier de

; Viana, Denizar

; Saraiva, José Francisco Kerr

; Canesin, Manoel Fernandes

; Oliveira, Glaucia Maria Moraes de

; Mesquita, Evandro Tinoco

Arquivos Brasileiros de Cardiologia

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Set 2021, Volume 117 Nº 3 Páginas 561 - 598

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210718 330 downloads

From Spanish Flu to Syndemic COVID-19: long-standing sanitarian vulnerability of Manaus, warnings from the Brazilian rainforest gateway
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RIBEIRO, SÉRVIO P.

; REIS, ALEXANDRE B.

; DÁTTILO, WESLEY

; SILVA, ALCIDES V.C. DE CASTRO E

; BARBOSA, EDUARDO AUGUSTO G.

; COURA-VITAL, WENDEL

; GÓES-NETO, ARISTÓTELES

; AZEVEDO, VASCO A.C.

; FERNANDES, GERALDO WILSON

Anais da Academia Brasileira de Ciências

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2021, Volume 93 elocation e20210431

Resumo: En | Texto: En | PDF: En

Abstract A second deadlier wave of COVID-19 and the causes of the recent public health collapse of Manaus are compared with the Spanish flu events in that city, and Brazil. Historic sanitarian problems, and its hub position in the Brazilian airway network are combined drivers of deadly events related to COVID-19. These drivers were amplified by misleading governance, highly transmissible variants, and relaxation of social distancing. Several of these same factors may also have contributed to the dramatically severe outbreak of H1N1 in 1918, which caused the death of 10% of the population in seven months. We modelled Manaus parameters for the present pandemic and confirmed that lack of a proper social distancing might select the most transmissible variants. We succeeded to reproduce a first severe wave followed by a second stronger wave. The model also predicted that outbreaks may last for up to five and half years, slowing down gradually before the disease disappear. We validated the model by adjusting it to the Spanish Flu data for the city, and confirmed the pattern experienced by that time, of a first stronger wave in October-November 1918, followed by a second less intense wave in February-March 1919.

https://doi.org/10.1590/0001-3765202120210431 337 downloads

Diretriz Brasileira de Cardio-oncologia – 2020
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Hajjar, Ludhmila Abrahão

; Costa, Isabela Bispo Santos da Silva da

; Lopes, Marcelo Antônio Cartaxo Queiroga

; Hoff, Paulo Marcelo Gehm

; Diz, Maria Del Pilar Estevez

; Fonseca, Silvia Moulin Ribeiro

; Bittar, Cristina Salvadori

; Rehder, Marília Harumi Higuchi dos Santos

; Rizk, Stephanie Itala

; Almeida, Dirceu Rodrigues

; Fernandes, Gustavo dos Santos

; Beck-da-Silva, Luís

; Campos, Carlos Augusto Homem de Magalhães

; Montera, Marcelo Westerlund

; Alves, Sílvia Marinho Martins

; Fukushima, Júlia Tizue

; Santos, Maria Verônica Câmara dos

; Negrão, Carlos Eduardo

; Silva, Thiago Liguori Feliciano da

; Ferreira, Silvia Moreira Ayub

; Malachias, Marcus Vinicius Bolivar

; Moreira, Maria da Consolação Vieira

; Valente Neto, Manuel Maria Ramos

; Fonseca, Veronica Cristina Quiroga

; Soeiro, Maria Carolina Feres de Almeida

; Alves, Juliana Barbosa Sobral

; Silva, Carolina Maria Pinto Domingues Carvalho

; Sbano, João

; Pavanello, Ricardo

; Pinto, Ibraim Masciarelli F.

; Simão, Antônio Felipe

; Dracoulakis, Marianna Deway Andrade

; Hoff, Ana Oliveira

; Assunção, Bruna Morhy Borges Leal

; Novis, Yana

; Testa, Laura

; Alencar Filho, Aristóteles Comte de

; Cruz, Cecília Beatriz Bittencourt Viana

; Pereira, Juliana

; Garcia, Diego Ribeiro

; Nomura, Cesar Higa

; Rochitte, Carlos Eduardo

; Macedo, Ariane Vieira Scarlatelli

; Marcatti, Patricia Tavares Felipe

; Mathias Junior, Wilson

; Wiermann, Evanius Garcia

; Val, Renata do

; Freitas, Helano

; Coutinho, Anelisa

; Mathias, Clarissa Maria de Cerqueira

; Vieira, Fernando Meton de Alencar Camara

; Sasse, André Deeke

; Rocha, Vanderson

; Ramires, José Antônio Franchini

; Kalil Filho, Roberto

Arquivos Brasileiros de Cardiologia

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Nov 2020, Volume 115 Nº 5 Páginas 1006 - 1043

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201006 4180 downloads

10.

Ingredientes de um prato exótico: saúde e alimentação em pauta no primeiro Congresso Médico Amazônico (Belém, 1939)
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Miranda, Aristóteles Guilliod de

; Abreu Jr, José Maria de Castro

; Muniz, Érico Silva

História, Ciências, Saúde-Manguinhos

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Mar 2020, Volume 27 Nº 1 Páginas 219 - 237

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O artigo apresenta o contexto de organização e realização do primeiro Congresso Médico Amazônico, ocorrido na cidade de Belém, em agosto de 1939. Inserido na tradição da divulgação científica de seu tempo, o evento reuniu parte das elites médicas da região e contou com a participação de convidados reconhecidos nacional e internacionalmente, entre eles Josué de Castro e Dante Costa. Tendo como principais fontes os materiais impressos produzidos pelo congresso e as notícias veiculadas nos jornais paraenses, este texto examina a concentração de debates sobre as carências alimentares da Amazônia observando a compreensão acadêmica e política das faces do fenômeno para a região.

Abstract The context in which the first Amazonian Medical Congress was organized and held in Belém, Brazil, in August 1939, is presented. Within the tradition of scientific communication of its time, the event brought together some of the region’s medical elites and also had nationally and internationally renowned guest participants, including Josué de Castro and Dante Costa. Taking the printed matter produced by the congress and news stories printed in the local press as its main sources, this study examines the accompanying debates on dietary deficiencies in the Amazon, observing academic and political understandings of the different aspects of the phenomenon for the region.

https://doi.org/10.1590/s0104-59702020000100013 748 downloads

11.

Worldwide COVID-19 spreading explained: traveling numbers as a primary driver for the pandemic
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RIBEIRO, SÉRVIO P.

; DÁTTILO, WESLEY

; BARBOSA, DAVID S.

; COURA-VITAL, WENDEL

; CHAGAS, IGOR A.S. DAS

; DIAS, CAMILA P.

; SILVA, ALCIDES V.C. DE CASTRO E

; MORAIS, MARIA HELENA F.

; GÓES-NETO, ARISTÓTELES

; AZEVEDO, VASCO A.C.

; FERNANDES, GERALDO WILSON

; REIS, ALEXANDRE B.

Anais da Academia Brasileira de Ciências

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2020, Volume 92 Nº 4 elocation e20201139

Resumo: En | Texto: En | PDF: En

Abstract The spread of SARS-CoV-2 and the distribution of cases worldwide followed no clear biogeographic, climatic, or cultural trend. Conversely, the internationally busiest cities in all countries tended to be the hardest hit, suggesting a basic, mathematically neutral pattern of the new coronavirus early dissemination. We tested whether the number of flight passengers per time and the number of international frontiers could explain the number of cases of COVID-19 worldwide by a stepwise regression. Analysis were taken by 22 May 2020, a period when one would claim that early patterns of the pandemic establishment were still detectable, despite of community transmission in various places. The number of passengers arriving in a country and the number of international borders explained significantly 49% of the variance in the distribution of the number of cases of COVID-19, and number of passengers explained significantly 14.2% of data variance for cases per million inhabitants. Ecological neutral theory may explain a considerable part of the early distribution of SARS-CoV-2 and should be taken into consideration to define preventive international actions before a next pandemic.

https://doi.org/10.1590/0001-3765202020201139 2277 downloads

12.

Increased prevalence of hypertension among people living with HIV: where to begin?
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Costa, Aldrey Nascimento

; Val, Fernando

; Macedo, Álvaro Elias

; Cubas-Vega, Nadia

; Tejo, Paola López Del

; Marques, Marly M.

; Alencar Filho, Aristóteles Comte de

; Lacerda, Marcus Vinicius Guimarães de

Revista da Sociedade Brasileira de Medicina Tropical

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2020, Volume 53 elocation e20190564

Resumo: En | Texto: En | PDF: En

Abstract INTRODUCTION: Cardiovascular diseases (CDVs) have become increasingly important for progressively older people living with HIV (PLHIV). Identification of gaps requiring improvement in the care cascade for hypertension, a primary risk factor for CVDs, is of utmost importance. This study analyzed the prevalence of hypertensive status and described the care cascade for hypertension screening, diagnosis, treatment, treatment adherence, and management in PLHIV. METHODS: This cross-sectional study included 298 PLHIV (age >40 years) who visited a referral center in the western Brazilian Amazon. Data were collected through a structured questionnaire interview and medical examinations. Thus, information regarding sociodemographic and clinical aspects, blood pressure, weight, height, body mass index, and laboratory profile was obtained. Descriptive and analytical statistics were performed, and results were considered significant ifp <0.05. RESULTS: In total, 132 (44.3%) participants reported that their blood pressure was never measured. The prevalence of hypertension was found to be 35.9% (107/298). Of these 107 participants, only 36 (33.6%) had prior knowledge of their hypertensive status, and 19 of 36 (52.7%) participants had visited a physician or cardiologist to seek treatment. Adherence to the BP-lowering treatment was noted in 11 (10.2%) participants. CONCLUSIONS: An increased prevalence of hypertension was found, and most of the hypertensive participants were unaware of their hypertensive status. In addition, blood pressure control was poor in the study population. This indicated that public health professionals did not sufficiently consider the full spectrum of healthcare and disease management for PLHIV.

https://doi.org/10.1590/0037-8682-0564-2019 660 downloads

13.

Síndrome linfoproliferativo autoinmune. Actualización y revisión
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Suárez-Gutiérrez, Marcos

; Yamazaki-Nakashimada, Marco Antonio

; Espinosa, Sara

; Blancas-Galicia, Lizbeth

; Lugo-Reyes, Saúl Oswaldo

; Álvarez-Cardona, Aristóteles

Revista alergia México

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Dez 2019, Volume 66 Nº 4 Páginas 456 - 473

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract The autoimmune lymphoproliferative syndrome (ALPS) is an inborn immunity error, which is the result of a heterogeneous group of mutations in the genes that regulate the apoptosis phenomenon. It typically appears in the first years of life. The most common clinical signs are lymphoid expansion with lymphadenopathy, splenomegaly, and hepatomegaly; immune disease with different types of cytopenia, including thrombocytopenia, hemolytic anemia, and lymphoma. The lab abnormalities that facilitate the diagnosis of ALPS include the presence of double negative alpha/beta T cells, high interleukin levels, vitamin B12 in the blood, and FAS-mediated defective apoptosis in the in vitro assay. The treatment of ALPS is focused on three aspects: The treatment of the manifestations of the disease, the prevention/treatment of complications, and the curative treatment (hematopoietic progenitor cell transplantation [HPCT]). The use of immunosuppressive therapy is suggested only for severe complications of lymphoproliferation or concomitant autoimmune manifestations. Splenectomy is not recommended for autoimmune manifestations in patients with ALPS. HPCT is reserved for selected patients. The survival rate to 50 years is estimated at 85% for patients with FAS deficiency.

Resumen El síndrome linfoproliferativo autoinmune (ALPS, autoimmune lymphoproliferative syndrome) es un error innato de la inmunidad, resultado de un grupo heterogéneo de alteraciones en los genes que regulan el fenómeno de apoptosis. Se manifiesta típicamente en los primeros años de vida. Las manifestaciones clínicas más comunes son la expansión linfoide con linfadenopatía, esplenomegalia y hepatomegalia, enfermedad autoinmune con citopenias, incluyendo trombocitopenia y anemia hemolítica, así como linfoma. Las anomalías de laboratorio que facilitan el diagnóstico de ALPS incluyen presencia de células alfa-beta T doble negativas, niveles elevados de interleucina 10, vitamina B12 en sangre y apoptosis defectuosa mediada por FAS en ensayo in vitro. El tratamiento de ALPS se centra en tres aspectos: el tratamiento de las manifestaciones de la enfermedad, la prevención y tratamiento de las complicaciones y el tratamiento curativo (trasplante de células progenitoras hematopoyéticas [TCPH]). Se sugiere el uso de tratamiento inmunosupresor solo para las complicaciones graves de la linfoproliferación o manifestaciones autoinmunes concomitantes. La esplenectomía no se recomienda para las manifestaciones autoinmunes en pacientes con ALPS. El TCPH se reserva para pacientes seleccionados. La tasa de supervivencia a 50 años se estima en 85 % para los pacientes con deficiencia de FAS.

https://doi.org/10.29262/ram.v66i4.646 5699 downloads

14.

Sensibilización a aeroalérgenos en pacientes con rinitis alérgica en Aguascalientes, México
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Suárez-Gutiérrez, Marcos

; Macías-Garza, Jorge Eduardo

; López-Ortiz, Daniela Jazmín

; Fuentes, Brenda

; Álvarez-Cardona, Aristóteles

Revista alergia México

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Dez 2019, Volume 66 Nº 4 Páginas 388 - 393

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Background: Allergic rhinitis is the most common allergic disease worldwide and it is caused by a reaction of hypersensitivity to aeroallergens. To our knowledge, there aren’t any previous studies of aeroallergenic sensitization in Aguascalientes, Mexico. Objective: To describe the sensitization to aeroallergens in patients with allergic rhinitis who have been treated at a private clinic in Aguascalientes, Mexico. Methods: A descriptive, cross-sectional and retrospective study was done in which patients diagnosed with allergic rhinitis were included. Skin prick tests with 32 allergenic extracts were carried out and the frequencies at each were determined. Results: In total, 350 patients were analyzed. The most frequent aeroallergens were grass pollens (74.8%), followed by tree pollens (64.8%) and dust mites Dermatophagoides pteronyssinus (64%). The group of patients under 20 years of age was predominant (67.1%), followed by the group of 21 to 40 years old (22.5%). Conclusion: This research provides information about regional patterns of sensitization, which shall facilitate diagnostic tests in the region and the best practices of specific immunotherapy.

Resumen Antecedentes: La rinitis alérgica es la enfermedad alérgica más común en el mundo y es causada por hipersensibilidad a los aeroalérgenos. Hasta donde sabemos, no hay estudios previos de sensibilización aeroalergénica en Aguascalientes, México. Objetivo: Describir la sensibilización a aeroalérgenos en pacientes con rinitis alérgica tratados en una clínica privada en Aguascalientes, México. Métodos: Estudio descriptivo, transversal y retrospectivo; se incluyeron pacientes diagnosticados con rinitis alérgica. Se realizaron pruebas cutáneas con 32 extractos alergénicos y se determinaron las frecuencia de reacción a cada uno. Resultados: En total se analizaron 350 pacientes. Los aeroalérgenos más frecuentes fueron los pólenes de pastos (74.8%), seguidos por los pólenes de árboles (64.8%) y Dermatophagoides pteronyssinus (64%). El grupo de edad predominante fue el menor de 20 años (67.1%), seguido del grupo de 21 a 40 años (22.5%). Conclusión: La investigación proporciona información sobre los patrones regionales de sensibilización, que facilitará las pruebas de diagnóstico en la región y las mejores prácticas de inmunoterapia específica.

https://doi.org/10.29262/ram.v66i4.634 523 downloads

15.

Dietary composition and trophic level of Hypanus marianae (Myliobatiformes: Dasyatidae), captured off Pernambuco coast, Brazil
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Queiroz, Aristóteles P.N.

; Araújo, Maria L.G.

; Lessa, Rosângela P.T.

Latin american journal of aquatic research

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Nov 2019, Volume 47 Nº 5 Páginas 808 - 817

Resumo: En | Texto: En | PDF: En

ABSTRACT Hypanus marianae, a stingray endemic to Brazil, inhabits coastal coral reef areas occurring in the landings of artisanal fisheries. The present study aimed to characterize the diet of this species captured off Pernambuco. We obtained 77 stomachs with contents: 52.27% female, 47.72% male. DW ranged from 15 to 37.80 cm mean of 26.53 ± 4.82 cm. Four higher taxonomic prey categories were identified: Arthropoda, Annelida, Chordata and Sipuncula. The most important item in the diet was Polychaeta (40.65% IRI), followed by Leptochela serratorbita (30.35% IRI), suborder Dendrobranchiata (10.18% IRI), order Isopoda (4.19% IRI), and Meiosquilla schmitti (3.56% IRI). H. marianae displays specialized predatory habit (BA = 0.06) primarily based on shrimps (42.36% IRI) and polychaetes (40.65% IRI). There was no significant difference in the diet by sex or in sexual development stages. However, neonates fed on decapods crustaceans (70.68%) and polychaetes (17.09%). For immatures, decapod crustaceans (69.5%) and polychaetes (25.86%) made up most of their diet. The adults feed mainly on polychaetes (62.79%) and crustacean decapods (30.47%), with a slight increase of fish (5.46%). The trophic level (TL) estimated was based on stomach content analysis was 3.66 and estimated on the analysis of stable isotopes being 3.29, which classified the species as a mesopredator.

https://doi.org/10.3856/vol47-issue5-fulltext-10 522 downloads

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